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Protection Against Ionizing Radiation April 5, 2007

Posted by healthyself in Animal Research, Antioxidants, Bioeffects, Biological Activity, Biological Effects, Blogroll, Brain Cancer, Breast Cancer, Cancer Protection, Cell changes, cell membrane, Cells, Children's health, Chromosomal damage, Cordless Phones, Cytotoxic Effects, Electrical Pulses, Electrical Surges, Electrical Wiring, Electromagnetic Communications, Electromagnetic Field, Electromagnetic pollution, Electromagnetic Radiation, Electromagnetic waves, Electrosensitivity, Electrosmog, ELF, Emergency Medicine, EMF Research, EMF's, EMR, Endocrine, Environment, Epidemiology, Free Radicals, Frequencies, genetic damage, Health related, HF, High Frequencies, high voltage transmission lines, Homes, HOuseholds, Hz, Immune system, Insomnia, Interdisciplinary, ionizing radiation, Long Term Health Risks, Low Frequencies, Lymphoma, Medical Research, Melatonin, Metabolic Changes, MF, MHz, Microwave exposure, Networks, Non-Thermal Levels, Oscillate, Penetration, Pineal Gland, Pulsed Radiation, Pulses, radiation, Radio Waves, radioprotector, Research, Research Needed, ringtones, Risk of Disease, Safe Levels, scavenger, Sick People, Sleep disturbances, Solutions, Stress, subcellular structures, Symptoms, Telecommunications, terrorism, toxicity, Who is Affected?, Workplace, X-Rays.
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“Melatonin (N-acetyl-5-methoxytryptamine), the chief secretory product of the pineal gland in the brain, is well known for its functional versatility. In hundreds of investigations, melatonin has been documented as a direct free radical scavenger and an indirect antioxidant, as well as an important immunomodulatory agent. The radical scavenging ability of melatonin is believed to work via electron donation to detoxify a variety of reactive oxygen and nitrogen species, including the highly toxic hydroxyl radical. It has long been recognized that the damaging effects of ionizing radiation are brought about by both direct and indirect mechanisms. The direct action produces disruption of sensitive molecules in the cells, whereas the indirect effects ( approximately 70%) result from its interaction with water molecules, which results in the production of highly reactive free radicals such as *OH, *H, and e(aq)- and their subsequent action on subcellular structures. The hydroxyl radical scavenging ability of melatonin was used as a rationale to determine its radioprotective efficiency. Indeed, the results from many in vitro and in vivo investigations have confirmed that melatonin protects mammalian cells from the toxic effects of ionizing radiation. Furthermore, several clinical reports indicate that melatonin administration, either alone or in combination with traditional radiotherapy, results in a favorable efficacy:toxicity ratio during the treatment of human cancers. This article reviews the literature from laboratory investigations that document the ability of melatonin to scavenge a variety of free radicals (including the hydroxyl radical induced by ionizing radiation) and summarizes the evidence that should be used to design larger translational research-based clinical trials using melatonin as a radioprotector and also in cancer radiotherapy. The potential use of melatonin for protecting individuals from radiation terrorism is also considered.”

Melatonin as a radioprotective agent: a review.

Vijayalaxmi, Reiter RJ, Tan DX, Herman TS, Thomas CR Jr.

Department of Radiation Oncology, The University of Texas Health Science Center, San Antonio, 78229, USA. vijay@uthscsa.edu

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15183467

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